Exfoliation syndrome is a leading cause of glaucoma worldwide. However, progress in developing better therapies for exfoliation glaucoma has been hindered by the lack of an animal model. Dr. John Fingert and Dr. Michael Anderson have received a two-year, $418,000 research award from the National Eye Institute to create and study animal models of exfoliation glaucoma using a genome editing approach.
Fingert Lab NewsFriday, January 25, 2019 - 10:30
Fingert Lab NewsThursday, January 10, 2019 - 16:00
Post-doctoral fellow in the Glaucoma Genetics Lab, Ankur Jain, has been awarded a $50,000 Shaffer Grant for his proposal, "Autophagy-targeted Treatment for Myocilin-associated Glaucoma”. These funds will support his research to determine how gene-defects cause optic nerve damage and glaucoma.
Fingert Lab NewsWednesday, January 9, 2019 - 09:00
Dr. Fingert discusses myocilin mutations and how likely they are to cause glaucoma in an invited commentary in JAMA Ophthalmology. Read more about it here.
Fingert Lab NewsThursday, October 4, 2018 - 15:00
We conducted the first ever analysis of an eye donated for research from a patient with glaucoma caused by a myocilin mutation. Our study of this eye shows how myocilin mutations may cause glaucoma. We detected abnormal accumulation of myocilin protein within the cells of the eye that regulate eye pressure. (trabecular meshwork cells). Ultimately this abnormality may cause eye pressure to rise and lead to glaucoma. Read more about this report here.
Lab Graduate Student, Carly Van der Heide wins Travel Fellowship to Research Meeting in Belfast, Northern IrelandFingert Lab NewsWednesday, July 18, 2018 - 13:45
Carly will present her research in the genetic basis of glaucoma in patients of African heritage at the biennial meeting of the International Society for Eye Research (ISER) in Belfast, Northern Ireland. She was awarded a travel fellowship from ISER and from the Knights Templar Eye Foundation to support her travel to share her research at this important meeting.
Fingert Lab NewsThursday, July 5, 2018 - 11:15
The Glaucoma Genetics Lab is thrilled to announce that Ankur Jain PHD will be joining the team as a post-doctoral fellow. Ankur completed his PHD training with Dr. Abbot Clark at the University of Northern Texas and his first post-doctoral fellowship with Dr. Val Sheffield, our close collaborator here at the Institute for Vision Research. Ankur will work with Budd Tucker in his stem cell facility and take the lead in the Glaucoma Center’s stem cell biology efforts to study optic atrophy and glaucoma.
Fingert Lab NewsWednesday, February 21, 2018 - 12:15
Dr. John Fingert, Dr. Todd Scheetz, and Dr. Michael Anderson were awarded an R21 grant to search for the genes that cause glaucoma associated with pigment release from the iris. This award will provide support ($419,000 over two years) for studying whole exomes from 550 pigmentary glaucoma patients and normal subjects.
Fingert Lab NewsFriday, January 19, 2018 - 09:45
The Glaucoma Genetics Lab identified a defect in the OPA1 gene that causes optic nerve atrophy that is dominantly inherited in a large family. We created a model of the protein encoded by the OPA1 gene (shown above) and we studied the effects of the disease-causing mutation on the protein structure and function. Read more about the discovery here.
Fingert Lab NewsThursday, January 11, 2018 - 15:00
In partnership with Dr. Alward, Dr. Kwon, Dr. Bettis, and Dr. Sears, the Fingert Lab has collected skin biopsies from over 50 patients with exfoliation glaucoma. The Glaucoma Foundation has provided funds for the lab to study these skin cells to identify abnormalities in function (i.e. energy production or waste management) and their role in exfoliation syndrome.
Fingert Lab NewsThursday, December 7, 2017 - 07:15
In a world-wide collaboration, we used genome-sequencing approaches to precisely define the extent and organization of TBK1 gene duplications and triplications in glaucoma patients. Read more about it here.